Development and implementation of efficient noise suppression methods for emission computed tomography

In PET and SPECT imaging, iterative reconstruction is now widely used due to its capability of incorporating into the reconstruction process a physics model and Bayesian statistics involved in photon detection. Iterative reconstruction methods rely on regularization terms to suppress image noise and render radiotracer distribution with good image quality. The choice of regularization method substantially affects the appearances of reconstructed images, and is thus a critical aspect of the reconstruction process. Major contributions of this work include implementation and evaluation of various new regularization methods. Previously, our group developed a preconditioned alternating projection algorithm (PAPA) to optimize the emission computed tomography (ECT) objective function with the non-differentiable total variation (TV) regularizer. The algorithm was modified to optimize the proposed reconstruction objective functions. First, two novel TV-based regularizers—high-order total variation (HOTV) and infimal convolution total variation (ICTV)—were proposed as alternative choices to the customary TV regularizer in SPECT reconstruction, to reduce “staircase” artifacts produced by TV. We have evaluated both proposed reconstruction methods (HOTV-PAPA and ICTV-PAPA), and compared them with the TV regularized reconstruction (TV-PAPA) and the clinical standard, Gaussian post-filtered, expectation-maximization reconstruction method (GPF-EM) using both Monte Carlo-simulated data and anonymized clinical data. Model-observer studies using Monte Carlo-simulated data indicate that ICTV-PAPA is able to reconstruct images with similar or better lesion detectability, compared with clinical standard GPF-EM methods, but at lower detected count levels. This implies that switching from GPF-EM to ICTV-PAPA can reduce patient dose while maintaining image quality for diagnostic use. Second, the 1 norm of discrete cosine transform (DCT)-induced framelet regularization was studied. We decomposed the image into high and low spatial-frequency components, and then preferentially penalized the high spatial-frequency components. The DCT-induced framelet transform of the natural radiotracer distribution image is sparse. By using this property, we were able to effectively suppress image noise without overly compromising spatial resolution or image contrast. Finally, the fractional norm of the first-order spatial gradient was introduced as a regularizer. We implemented 2/3 and 1/2 norms to suppress image spatial variability. Due to the strong penalty of small differences between neighboring pixels, fractional-norm regularizers suffer from similar cartoon-like artifacts as with the TV regularizer. However, when penalty weights are properly selected, fractional-norm regularizers outperform TV in terms of noise suppression and contrast recovery

Large room-temperature magnetoresistance in van der Waals ferromagnet/semiconductor junctions

The magnetic tunnel junction (MTJ) is the core component in memory technologies, such as the magnetic random-access memory, magnetic sensors and programmable logic devices. In particular, MTJs based on two-dimensional (2D) van der Waals (vdW) heterostructures offer unprecedented opportunities for low power consumption and miniaturization of spintronic devices. However, their operation at room temperature remains a challenge. Here, we report a large tunnel magnetoresistance (TMR) of up to 85% at room temperature (T = 300 K) in vdW MTJs based on a thin (< 10 nm) semiconductor spacer WSe2 layer embedded between two Fe3GaTe2 electrodes with intrinsic above-room-temperature ferromagnetism. The TMR in the MTJ increases with decreasing temperature up to 164% at T = 10 K. The demonstration of TMR in ultra-thin MTJs at room-temperature opens a realistic and promising route for next-generation spintronic applications beyond the current state of the art

Overexpression of Polo-like kinase1 (PLK1) in chondrosarcoma and its implications for cancer progression

Polo-like kinase1 (PLK1) is a new therapeutic target for osteosarcoma with good application prospects. Whether PLK1 is highly expressed in chondrosarcoma and whether PLK1 can be a potential therapeutic target for chondrosarcoma are worth exploring. However, PLK1 expression in chondrosarcoma is scarcely investigated. Therefore, we collected 11 cases of chondrosarcoma and 26 cases of osteochondroma with complete clinical pathological data and used immunohistochemical staining to detect the expression of PLK1 in chondrosarcoma and osteochondroma and then studied its significance and relationship with clinical pathological parameters. Our results showed that the positive expression rate of PLK1 in chondrosarcoma tissue (90.91%, 10/11) was significantly higher than the rate of osteochondroma tissues (53.85%, 14/26) (

Cirques of the Southeastern Tibetan Plateau and Their Links to Climatic and Non-Climatic Factors

Cirque morphology is used to reflect the patterns of paleoclimate, paleoglaciation, and landscape evolution. Cirque study has been conducted in the Gangdise Mountains of the southern Tibetan Plateau (TP) and the central TP (dominated by a weak Indian summer monsoon (ISM) or a continental climate). This study focused on the cirques in the southeastern TP, which is dominated by a strong ISM, to analyse the controlling factors on cirque morphology. A total of 361 cirques were mapped in the Taniantaweng Range of the southeastern TP, and their metrics were calculated. The results showed that the cirque sizes increased with temperature and decreased with precipitation, which may be due to the development of valley-type glaciers and the effect of non-climatic factors. The cirques tended to face NE, implying that they prefer leeward slopes, and they were under the &lsquo;morning&ndash;afternoon&rsquo; effect. With altitude, the tendency of the cirque aspect shifted from N to SE, and the cirque size decreased. The former may indicate the ability of the high altitude to support cirque development on climatically unfavourable slopes; the latter may be due to the development of valley-type glaciers or insufficient space for cirque development. The cirque size and shape did not show statistical differences between aspects. The cirques on soft bedrocks had larger heights than those on hard bedrocks, indicating that soft bedrocks promote subglacial erosion. A comparison with the results of the western, central, and eastern sectors of the Gangdise Mountains and the central TP reveals that the strength of the ISM did not necessarily increase the cirque density but limited the cirque size on a regional scale. The CFA did not show a reverse relationship with precipitation, but it showed a positive correlation with the cirque Zmean, which implies that the CFA was greatly affected by altitude, and its distribution does not always reflect paleoclimatic patterns

Mechanism of Drag Reduction in Floating Plate of Paddy Field Based on CFD

In order to study drag reduction mechanism in mud parts’ operation of surface machine tools for paddy field, this paper takes floating plate, the main working part of laminating mechanism, as the research object and systematically analyzes the mechanism of action of elevation angle, curved angle, penetrating angle, and local microstructure of floating plate on working resistance and local fluid flow characteristics of the laminating structure based on VOF model in Fluent. Using ship mechanics theory and fluid lubrication theory, the drag reduction mechanism under different structural parameters of the floating plate is analyzed. The results show that, compared with the ordinary floating plate, the pressure difference resistance can be reduced by increasing the elevation angle by 60°, curved angle by 20°, and mud separation angle by 20°. The increase of the concave nonsmooth bottom surface structure can reduce viscous frictional resistance, and the total working resistance after structural optimization is comparatively reduced by 48.3%, with lowered hilling height in the forward direction and improved lubrication condition of the bottom surface, forming liquid lubrication effect. This study can provide theoretical references for the optimization design of muddy soil mud parts, mud-machine interaction research, and the development of paddy field laminating mechanism

Time-Shift Multiscale Fuzzy Entropy and Laplacian Support Vector Machine Based Rolling Bearing Fault Diagnosis

Multiscale entropy (MSE), as a complexity measurement method of time series, has been widely used to extract the fault information hidden in machinery vibration signals. However, the insufficient coarse graining in MSE will result in fault pattern information missing and the sample entropy used in MSE at larger factors will fluctuate heavily. Combining fractal theory and fuzzy entropy, the time shift multiscale fuzzy entropy (TSMFE) is put forward and applied to the complexity analysis of time series for enhancing the performance of MSE. Then TSMFE is used to extract the nonlinear fault features from vibration signals of rolling bearing. By combining TSMFE with the Laplacian support vector machine (LapSVM), which only needs very few marked samples for classification training, a new intelligent fault diagnosis method for rolling bearing is proposed. Also the proposed method is applied to the experiment data analysis of rolling bearing by comparing with the existing methods and the analysis results show that the proposed fault diagnosis method can effectively identify different states of rolling bearing and get the highest recognition rate among the existing methods

An Active Electromagnetically Induced Transparency (EIT) Metamaterial Based on Conductive Coupling

In this paper, we demonstrate an active metamaterial manifesting electromagnetically induced transparency (EIT) effect in the microwave regime. The metamaterial unit cell consists of a double-cross structure, between which a varactor diode is integrated. The capacitance of the diode is controlled by a reversed electrical bias voltage supplied through two connected strip lines. The diode behaves as a radiative resonant mode and the strip lines as a non-radiative resonant mode. The two modes destructively interference with each other through conductive coupling, which leads to a transmission peak in EIT effect. Through electrical control of the diode capacitance, the transmission peak frequency is shifted from 7.4 GHz to 8.7 GHz, and the peak-to-dip ratio is tuned from 1.02 to 1.66, demonstrating a significant tunability